A series of anti-CEA/anti-DOTA bispecific antibody formats evaluated for pre-targeting: comparison of tumor uptake and blood clearance

A series of anti-tumor/anti-chelate bispecific antibody formats were developed for pre-targeted radioimmunotherapy. Based on the anti-carcinoembryonic antigen humanized hT84.66-M5A monoclonal antibody and the anti-DOTA C8.2.5 scFv antibody fragment, this cognate series of bispecific antibodies were...

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Detalhes bibliográficos
Main Authors: Yazaki, Paul J., Lee, Brian, Channappa, Divya, Cheung, Chia-Wei, Crow, Desiree, Chea, Junie, Poku, Erasmus, Li, Lin, Andersen, Jan Terje, Sandlie, Inger, Orcutt, Kelly Davis, Wittrup, K.Dane, Shively, John E., Raubitschek, Andrew, Colcher, David
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572755/
https://ncbi.nlm.nih.gov/pubmed/23175797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzs096
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