PET Imaging of (64)Cu-DOTA-scFv-Anti-PSMA Lipid Nanoparticles (LNPs): Enhanced Tumor Targeting over Anti-PSMA scFv or Untargeted LNPs

INTRODUCTION: Single chain (scFv) antibodies are ideal targeting ligands due to their modular structure, high antigen specificity and affinity. These monovalent ligands display rapid tumor targeting but have limitations due to their fast urinary clearance. METHODS: An anti-prostate membrane antigen...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Nucl Med Biol
Κύριοι συγγραφείς: Wong, Patty, Li, Lin, Chea, Junie, Delgado, Melissa K., Crow, Desiree, Poku, Erasmus, Szpikowska, Barbara, Bowles, Nicole, Channappa, Divya, Colcher, David, Wong, Jeffrey Y.C., Shively, John E., Yazaki, Paul J.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2017
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348925/
https://ncbi.nlm.nih.gov/pubmed/28126683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2017.01.004
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