PET Imaging of (64)Cu-DOTA-scFv-Anti-PSMA Lipid Nanoparticles (LNPs): Enhanced Tumor Targeting over Anti-PSMA scFv or Untargeted LNPs

INTRODUCTION: Single chain (scFv) antibodies are ideal targeting ligands due to their modular structure, high antigen specificity and affinity. These monovalent ligands display rapid tumor targeting but have limitations due to their fast urinary clearance. METHODS: An anti-prostate membrane antigen...

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Pubblicato in:Nucl Med Biol
Autori principali: Wong, Patty, Li, Lin, Chea, Junie, Delgado, Melissa K., Crow, Desiree, Poku, Erasmus, Szpikowska, Barbara, Bowles, Nicole, Channappa, Divya, Colcher, David, Wong, Jeffrey Y.C., Shively, John E., Yazaki, Paul J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5348925/
https://ncbi.nlm.nih.gov/pubmed/28126683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2017.01.004
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