Brain cell type-specific enhancer-promoter interactome maps and disease risk association

Non-coding genetic variation is a major driver of phenotypic diversity, but functional interpretation is challenging. To better understand common genetic variation associated with brain diseases, we defined non-coding regulatory regions for major cell types of the human brain. Whereas psychiatric di...

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Pubblicato in:Science
Autori principali: Nott, Alexi, Holtman, Inge R., Coufal, Nicole G., Schlachetzki, Johannes C.M., Yu, Miao, Hu, Rong, Han, Claudia Z., Pena, Monique, Xiao, Jiayang, Wu, Yin, Keulen, Zahara, Pasillas, Martina P., O’Connor, Carolyn, Nickl, Christian K., Schafer, Simon T., Shen, Zeyang, Rissman, Robert A., Brewer, James B., Gosselin, David, Gonda, David D., Levy, Michael L., Rosenfeld, Michael G., McVicker, Graham, Gage, Fred H., Ren, Bing, Glass, Christopher K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028213/
https://ncbi.nlm.nih.gov/pubmed/31727856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay0793
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