Transcriptional control of microglia phenotypes in health and disease

Por Holtman, Inge R., Skola, Dylan, Glass, Christopher K.
Publicado no J Clin Invest (2017)

Identification of a conserved and acute neurodegeneration‐specific microglial transcriptome in the zebrafish

Por Oosterhof, Nynke, Holtman, Inge R., Kuil, Laura E., van der Linde, Herma C., Boddeke, Erik W.G.M., Eggen, Bart J.L., van Ham, Tjakko J.
Publicado no Glia (2016)

Lymphocryptovirus Infection of Nonhuman Primate B Cells Converts Destructive into Productive Processing of the Pathogenic CD8 T Cell Epitope in Myelin Oligodendrocyte Glycoprotein

Por Jagessar, S. Anwar, Holtman, Inge R., Hofman, Sam, Morandi, Elena, Heijmans, Nicole, Laman, Jon D., Gran, Bruno, Faber, Bart W., van Kasteren, Sander I., Eggen, Bart J. L., ‘t Hart, Bert A.
Publicado no J Immunol (2016)

Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1

Por Szulzewsky, Frank, Pelz, Andreas, Feng, Xi, Synowitz, Michael, Markovic, Darko, Langmann, Thomas, Holtman, Inge R., Wang, Xi, Eggen, Bart J. L., Boddeke, Hendrikus W. G. M., Hambardzumyan, Dolores, Wolf, Susanne A., Kettenmann, Helmut
Publicado no PLoS One (2015)

Increased White Matter Inflammation in Aging- and Alzheimer’s Disease Brain

Por Raj, Divya, Yin, Zhuoran, Breur, Marjolein, Doorduin, Janine, Holtman, Inge R., Olah, Marta, Mantingh-Otter, Ietje J., Van Dam, Debby, De Deyn, Peter P., den Dunnen, Wilfred, Eggen, Bart J. L., Amor, Sandra, Boddeke, Erik
Publicado no Front Mol Neurosci (2017)

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

Por Holtman, Inge R, Raj, Divya D, Miller, Jeremy A, Schaafsma, Wandert, Yin, Zhuoran, Brouwer, Nieske, Wes, Paul D, Möller, Thomas, Orre, Marie, Kamphuis, Willem, Hol, Elly M, Boddeke, Erik W G M, Eggen, Bart J L
Publicado no Acta Neuropathol Commun (2015)

A novel microglial subset plays a key role in myelinogenesis in developing brain

Por Wlodarczyk, Agnieszka, Holtman, Inge R, Krueger, Martin, Yogev, Nir, Bruttger, Julia, Khorooshi, Reza, Benmamar‐Badel, Anouk, de Boer‐Bergsma, Jelkje J, Martin, Nellie A, Karram, Khalad, Kramer, Isabella, Boddeke, Erik WGM, Waisman, Ari, Eggen, Bart JL, Owens, Trevor
Publicado no EMBO J (2017)

Telomere shortening leads to an acceleration of synucleinopathy and impaired microglia response in a genetic mouse model

Por Scheffold, Annika, Holtman, Inge R., Dieni, Sandra, Brouwer, Nieske, Katz, Sarah-Fee, Jebaraj, Billy Michael Chelliah, Kahle, Philipp J., Hengerer, Bastian, Lechel, André, Stilgenbauer, Stephan, Boddeke, Erik W. G. M., Eggen, Bart J. L., Rudolph, Karl-Lenhard, Biber, Knut
Publicado no Acta Neuropathol Commun (2016)

An environment-dependent transcriptional network specifies human microglia identity

Por Gosselin, David, Skola, Dylan, Coufal, Nicole G., Holtman, Inge R., Schlachetzki, Johannes C.M., Sajti, Eniko, Jaeger, Baptiste N., O’Connor, Carolyn, Fitzpatrick, Conor, Pasillas, Martina P., Pena, Monique, Adair, Amy, Gonda, David G., Levy, Michael L., Ransohoff, Richard M., Gage, Fred H., Glass, Christopher K.
Publicado no Science (2017)

Enhanced microglial pro‐inflammatory response to lipopolysaccharide correlates with brain infiltration and blood–brain barrier dysregulation in a mouse model of telomere shortening...

Por Raj, Divya D. A., Moser, Jill, van der Pol, Susanne M. A., van Os, Ronald P., Holtman, Inge R., Brouwer, Nieske, Oeseburg, Hisko, Schaafsma, Wandert, Wesseling, Evelyn M., den Dunnen, Wilfred, Biber, Knut P. H., de Vries, Helga E., Eggen, Bart J. L., Boddeke, Hendrikus W. G. M.
Publicado no Aging Cell (2015)

Analysis of genetically diverse macrophages reveals local and domain-wide mechanisms that control transcription factor binding and function

Por Link, Verena M., Duttke, Sascha H., Chun, Hyun B., Holtman, Inge R., Westin, Emma, Hoeksema, Marten A., Abe, Yohei, Skola, Dylan, Romanoski, Casey E., Tao, Jenhan, Fonseca, Greg, Troutman, Ty D., Spann, Nathanael, Strid, Tobias, Sakai, Mashito, Yu, Miao, Hu, Rong, Fang, Rongxin, Metzler, Dirk, Ren, Bing, Glass, Christopher K.
Publicado no Cell (2018)