Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

INTRODUCTION: Microglia are tissue macrophages of the central nervous system that monitor brain homeostasis and react upon neuronal damage and stress. Aging and neurodegeneration induce a hypersensitive, pro-inflammatory phenotype, referred to as primed microglia. To determine the gene expression si...

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Bibliographic Details
Published in:Acta Neuropathol Commun
Main Authors: Holtman, Inge R, Raj, Divya D, Miller, Jeremy A, Schaafsma, Wandert, Yin, Zhuoran, Brouwer, Nieske, Wes, Paul D, Möller, Thomas, Orre, Marie, Kamphuis, Willem, Hol, Elly M, Boddeke, Erik W G M, Eggen, Bart J L
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489356/
https://ncbi.nlm.nih.gov/pubmed/26001565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-015-0203-5
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