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Analyses on clustering of the conserved residues at protein-RNA interfaces and its application in binding site identification

BACKGROUND: The maintenance of protein structural stability requires the cooperativity among spatially neighboring residues. Previous studies have shown that conserved residues tend to occur clustered together within enzyme active sites and protein-protein/DNA interfaces. It is possible that conserv...

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Pubblicato in:BMC Bioinformatics
Autori principali: Yang, Zhen, Deng, Xueqing, Liu, Yang, Gong, Weikang, Li, Chunhua
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7027071/
https://ncbi.nlm.nih.gov/pubmed/32066366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-020-3398-9
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