FOXM1 regulates leukemia stem cell quiescence and survival in MLL-rearranged AML

FOXM1, a known transcription factor, promotes cell proliferation in a variety of cancer cells. Here we show that Foxm1 is required for survival, quiescence and self-renewal of MLL-AF9 (MA9)-transformed leukemia stem cells (LSCs) in vivo. Mechanistically, Foxm1 upregulation activates the Wnt/β-cateni...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Sheng, Yue, Yu, Chunjie, Liu, Yin, Hu, Chao, Ma, Rui, Lu, Xinyan, Ji, Peng, Chen, Jianjun, Mizukawa, Benjamin, Huang, Yong, Licht, Jonathan D., Qian, Zhijian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7026046/
https://ncbi.nlm.nih.gov/pubmed/32066721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14590-9
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