Foxm1 is essential for quiescence and maintenance of hematopoietic stem cells

Foxm1, a mammalian Forkhead Box M1 protein, is known as a typical proliferation-associated transcription factor. Here, we find that Foxm1 was essential for maintenance of hematopoietic stem cell (HSC) quiescence and self-renewal capacity in vivo in mice. Reducing expression of FOXM1 also decreased q...

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Vydáno v:Nat Immunol
Hlavní autoři: Hou, Yu, Li, Wen, Sheng, Yue, Li, Liping, Huang, Yong, Zhang, Zhonghui, Zhu, Tongyu, Peace, David, Quigley, John G., Wu, Wenshu, Zhao, Youyang, Qian, Zhijian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4509925/
https://ncbi.nlm.nih.gov/pubmed/26147687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3204
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