FHL2 regulates hematopoietic stem cell functions under stress conditions

FHL2, a member of the four and one half LIM domain protein family, is a critical transcriptional modulator. Here, we identify FHL2 as a critical regulator of hematopoietic stem cells (HSCs) that is essential for maintaining HSC self-renewal under regenerative stress. We find that Fhl2 loss has limit...

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Pubblicato in:Leukemia
Autori principali: Hou, Yu, Wang, Xiaoqin, Li, LiPing, Fan, Rong, Chen, Ju, Zhu, Tongyu, Li, Wen, Jiang, Yanwen, Mittal, Nupur, Wu, Wenshu, Peace, David, Qian, Zhijian
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346553/
https://ncbi.nlm.nih.gov/pubmed/25179730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.254
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