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Prion protein PrP nucleic acid binding and mobilization implicates retroelements as the replicative component of transmissible spongiform encephalopathy

The existence of more than 30 strains of transmissible spongiform encephalopathy (TSE) and the paucity of infectivity of purified PrP(Sc), as well as considerations of PrP structure, are inconsistent with the protein-only (prion) theory of TSE. Nucleic acid is a strong contender as a second componen...

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Bibliografiske detaljer
Udgivet i:Arch Virol
Main Authors: Lathe, Richard, Darlix, Jean-Luc
Format: Artigo
Sprog:Inglês
Udgivet: Springer Vienna 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7024060/
https://ncbi.nlm.nih.gov/pubmed/32025859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00705-020-04529-2
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