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Prion protein PrP nucleic acid binding and mobilization implicates retroelements as the replicative component of transmissible spongiform encephalopathy

The existence of more than 30 strains of transmissible spongiform encephalopathy (TSE) and the paucity of infectivity of purified PrP(Sc), as well as considerations of PrP structure, are inconsistent with the protein-only (prion) theory of TSE. Nucleic acid is a strong contender as a second componen...

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Vydáno v:Arch Virol
Hlavní autoři: Lathe, Richard, Darlix, Jean-Luc
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Vienna 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7024060/
https://ncbi.nlm.nih.gov/pubmed/32025859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00705-020-04529-2
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