Recombinant PrP and Its Contribution to Research on Transmissible Spongiform Encephalopathies

The misfolding of the cellular prion protein (PrP(C)) into the disease-associated isoform (PrP(Sc)) and its accumulation as amyloid fibrils in the central nervous system is one of the central events in transmissible spongiform encephalopathies (TSEs). Due to the proteinaceous nature of the causal ag...

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Bibliografske podrobnosti
izdano v:Pathogens
Main Authors: Charco, Jorge M., Eraña, Hasier, Venegas, Vanessa, García-Martínez, Sandra, López-Moreno, Rafael, González-Miranda, Ezequiel, Pérez-Castro, Miguel Ángel, Castilla, Joaquín
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2017
Teme:
Review
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750591/
https://ncbi.nlm.nih.gov/pubmed/29240682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pathogens6040067
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