Recombinant PrP and Its Contribution to Research on Transmissible Spongiform Encephalopathies

The misfolding of the cellular prion protein (PrP(C)) into the disease-associated isoform (PrP(Sc)) and its accumulation as amyloid fibrils in the central nervous system is one of the central events in transmissible spongiform encephalopathies (TSEs). Due to the proteinaceous nature of the causal ag...

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Vydáno v:Pathogens
Hlavní autoři: Charco, Jorge M., Eraña, Hasier, Venegas, Vanessa, García-Martínez, Sandra, López-Moreno, Rafael, González-Miranda, Ezequiel, Pérez-Castro, Miguel Ángel, Castilla, Joaquín
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2017
Témata:
Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750591/
https://ncbi.nlm.nih.gov/pubmed/29240682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pathogens6040067
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