Mutations in the Neuraminidase-Like Protein of Bat Influenza H18N11 Virus Enhance Virus Replication in Mammalian Cells, Mice, and Ferrets

To characterize bat influenza H18N11 virus, we propagated a reverse genetics-generated H18N11 virus in Madin-Darby canine kidney subclone II cells and detected two mammal-adapting mutations in the neuraminidase (NA)-like protein (NA-F144C and NA-T342A, N2 numbering) that increased the virus titers i...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Zhong, Gongxun, Fan, Shufang, Hatta, Masato, Nakatsu, Sumiho, Walters, Kevin B., Lopes, Tiago J. S., Wang, Jessica I-Hsuan, Ozawa, Makoto, Karasin, Alexander, Li, Yan, Tong, Suxiang, Donis, Ruben O., Neumann, Gabriele, Kawaoka, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2020
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022354/
https://ncbi.nlm.nih.gov/pubmed/31801857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01416-19
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