Ectopic Expression of Rv0023 Mediates Isoniazid/Ethionamide Tolerance via Altering NADH/NAD(+) Levels in Mycobacterium smegmatis

Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) accounts for nearly 1.2 million deaths per annum worldwide. Due to the emergence of multidrug-resistant (MDR) Mtb strains, TB, a curable and avertable disease, remains one of the leading causes of morbidity and mortality. Isoniazid (INH) i...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Gupta, Shailesh Kumar, Angara, Rajendra Kumar, Yousuf, Suhail, Reddy, Chilakala Gangi, Ranjan, Akash
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020754/
https://ncbi.nlm.nih.gov/pubmed/32117088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2020.00003
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