Comparative analysis of mycobacterial NADH pyrophosphatase isoforms reveals a novel mechanism for isoniazid and ethionamide inactivation

NADH pyrophosphatase (NudC) catalyses the hydrolysis of NAD(H) to AMP and NMN(H) [nicotinamide mononucleotide (reduced form)]. NudC multiple sequence alignment reveals that homologues from most Mycobacterium tuberculosis isolates, but not other mycobacterial species, have a polymorphism at the highl...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Wang, Xu-De, Gu, Jing, Wang, Ting, Bi, Li-Jun, Zhang, Zhi-Ping, Cui, Zong-Qiang, Wei, Hong-Ping, Deng, Jiao-Yu, Zhang, Xian-En
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2011
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283747/
https://ncbi.nlm.nih.gov/pubmed/22026918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2011.07892.x
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker