Comparative analysis of mycobacterial NADH pyrophosphatase isoforms reveals a novel mechanism for isoniazid and ethionamide inactivation

NADH pyrophosphatase (NudC) catalyses the hydrolysis of NAD(H) to AMP and NMN(H) [nicotinamide mononucleotide (reduced form)]. NudC multiple sequence alignment reveals that homologues from most Mycobacterium tuberculosis isolates, but not other mycobacterial species, have a polymorphism at the highl...

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Main Authors: Wang, Xu-De, Gu, Jing, Wang, Ting, Bi, Li-Jun, Zhang, Zhi-Ping, Cui, Zong-Qiang, Wei, Hong-Ping, Deng, Jiao-Yu, Zhang, Xian-En
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3283747/
https://ncbi.nlm.nih.gov/pubmed/22026918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2011.07892.x
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