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Conformational and Dynamical Effects of Tyr32 Phosphorylation in K-Ras: Molecular Dynamics Simulation and Markov State Models Analysis

Phosphorylation of tyrosine 32 in K-Ras has been shown to influence function by disrupting the GTPase cycle. To shed light on the underlying mechanism and atomic basis of this process, we carried out a comparative investigation of the oncogenic G12D K-Ras mutant and its phosphorylated variant (pTyr3...

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Detalhes bibliográficos
Publicado no:J Phys Chem B
Main Authors: Khaled, Mohammed, Gorfe, Alemayehu, Sayyed-Ahmad, Abdallah
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7020251/
https://ncbi.nlm.nih.gov/pubmed/31419909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.9b05768
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