Passive immunization with an extended half-life monoclonal antibody protects Rhesus macaques against aerosolized ricin toxin

Inhalation of ricin toxin (RT), a Category B biothreat agent, provokes an acute respiratory distress syndrome marked by pro-inflammatory cytokine and chemokine production, neutrophilic exudate, and pulmonary edema. The severity of RT exposure is attributed to the tropism of the toxin’s B subunit (RT...

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Udgivet i:NPJ Vaccines
Main Authors: Roy, Chad J., Van Slyke, Greta, Ehrbar, Dylan, Bornholdt, Zachary A., Brennan, Miles B., Campbell, Lioudmila, Chen, Michelle, Kim, Do, Mlakar, Neil, Whaley, Kevin J., Froude, Jeffrey W., Torres-Velez, Fernando J, Vitetta, Ellen, Didier, Peter J., Doyle-Meyers, Lara, Zeitlin, Larry, Mantis, Nicholas J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018975/
https://ncbi.nlm.nih.gov/pubmed/32128254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41541-020-0162-0
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