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Spatial location of neutralizing and non-neutralizing B cell epitopes on domain 1 of ricin toxin’s binding subunit

Ricin toxin’s binding subunit (RTB) is a galactose-/N-acetylgalactosamine (Gal/GalNac)-specific lectin that mediates uptake and intracellular trafficking of ricin within mammalian cells. Structurally, RTB consists of two globular domains, each divided into three homologous sub-domains (α, β, γ). In...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Rong, Yinghui, Van Slyke, Greta, Vance, David J., Westfall, Jennifer, Ehrbar, Dylan, Mantis, Nicholas J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5507285/
https://ncbi.nlm.nih.gov/pubmed/28700745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180999
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