Increased expression of desmin and vimentin reduces bladder smooth muscle contractility via JNK2

Bladder dysfunction is associated with overexpression of the intermediate filament (IF) proteins desmin and vimentin in obstructed bladder smooth muscle (BSM). However, the mechanisms by which these proteins contribute to BSM dysfunction are not known. Previous studies have shown that desmin and vim...

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Veröffentlicht in:FASEB J
Hauptverfasser: Javed, Elham, Thangavel, Chellappagounder, Frara, Nagat, Singh, Jagmohan, Mohanty, Ipsita, Hypolite, Joseph, Birbe, Ruth, Braverman, Alan S., Den, Robert B, Rattan, Satish, Zderic, Stephen A, Deshpande, Deepak A, Penn, Raymond B., Ruggieri, Michael R., Chacko, Samuel, Boopathi, Ettickan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7018560/
https://ncbi.nlm.nih.gov/pubmed/31909533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201901301R
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