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Intrinsic Sexually Dimorphic Expression of the Principal Human CYP3A4 Correlated with Suboptimal Activation of GH/Glucocorticoid-Dependent Transcriptional Pathways in Men

Cytochrome P450 (CYP)3A4 is the principal and most abundant human isoform of CYP responsible for the metabolism of more than 50% of all consumed drugs and innumerable endogenous compounds. Expression of CYP3A4 is sexually dimorphic and regulated by the combined actions of GH and glucocorticoids. In...

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Detaylı Bibliyografya
Asıl Yazarlar: Thangavel, Chellappagounder, Boopathi, Ettickan, Shapiro, Bernard H.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Endocrine Society 2011
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230058/
https://ncbi.nlm.nih.gov/pubmed/21952236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1274
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