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Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action

REarranged during Transition (RET) is a tyrosine kinase associated with the development of several malignancies. Identification of RET kinase inhibitors promises valuable therapeutic tools for the intervention of RET-driven tumors. Most currently available tyrosine kinase inhibitors target the ATP b...

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Detalhes bibliográficos
Publicado no:Am J Cancer Res
Main Authors: Takeda, Kozue, Kawamoto, Yoshiyuki, Nagasaki, Yosuke, Okuno, Yusuke, Goto, Yuko, Iida, Machiko, Yajima, Ichiro, Ohgami, Nobutaka, Kato, Masashi
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017734/
https://ncbi.nlm.nih.gov/pubmed/32064171
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