TYK2 in Tumor Immunosurveillance

We review the history of the tyrosine kinase 2 (TYK2) as the founding member of the Janus kinase (JAK) family and outline its structure-function relation. Gene-targeted mice and hereditary defects of TYK2 in men have established the biological and pathological functions of TYK2 in innate and adaptiv...

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Bibliografiske detaljer
Udgivet i:Cancers (Basel)
Main Authors: Karjalainen, Anzhelika, Shoebridge, Stephen, Krunic, Milica, Simonović, Natalija, Tebb, Graham, Macho-Maschler, Sabine, Strobl, Birgit, Müller, Mathias
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7017180/
https://ncbi.nlm.nih.gov/pubmed/31936322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12010150
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