ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis

Meiotic recombination is initiated by SPO11-induced double-strand breaks (DSBs). In most mammals, the methyltransferase PRDM9 guides SPO11 targeting, and the ATM kinase controls meiotic DSB numbers. Following MRE11 nuclease removal of SPO11, the DSB is resected and loaded with DMC1 filaments for hom...

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Udgivet i:Nat Commun
Main Authors: Paiano, Jacob, Wu, Wei, Yamada, Shintaro, Sciascia, Nicholas, Callen, Elsa, Paola Cotrim, Ana, Deshpande, Rajashree A., Maman, Yaakov, Day, Amanda, Paull, Tanya T., Nussenzweig, André
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7016097/
https://ncbi.nlm.nih.gov/pubmed/32051414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14654-w
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