Targeting Src family kinase member Fyn by Saracatinib attenuated liver fibrosis in vitro and in vivo

Recent studies suggest that Src family kinase (SFK) plays important roles in systemic sclerosis and pulmonary fibrosis. However, how SFKs contributed to the pathogenesis of liver fibrosis remains largely unknown. Here, we investigated the role of Fyn, a member of SFK, in hepatic stellate cell (HSC)...

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Published in:Cell Death Dis
Main Authors: Du, Guifang, Wang, Jing, Zhang, Ting, Ding, Qiang, Jia, Xiaodong, Zhao, Xueke, Dong, Jinke, Yang, Xinrui, Lu, Shanshan, Zhang, Cuihong, Liu, Ze, Zeng, Zhen, Safadi, Rifaat, Qi, Ruizhao, Zhao, Xin, Hong, Zhixian, Lu, Yinying
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7016006/
https://ncbi.nlm.nih.gov/pubmed/32051399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2229-2
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