Fyn and Src are Effectors of Oncogenic EGFR Signaling in Glioblastoma Patients

Activating EGFR mutations are common in many cancers including glioblastoma. However, clinical responses to EGFR inhibitors are infrequent and short-lived. We demonstrate that the Src family kinases (SFKs) Fyn and Src are effectors of oncogenic EGFR signaling, enhancing invasion and tumor cell survi...

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Bibliografski detalji
Glavni autori: Lu, Kan V., Zhu, Shaojun, Cvrljevic, Anna, Huang, Tiffany T., Sarkaria, Shawn, Ahkavan, David, Dang, Julie, Dinca, Eduard B., Plaisier, Seema B., Oderberg, Isaac, Lee, Yohan, Chen, Zugen, Caldwell, Jeremy S., Xie, Yongmin, Loo, Joseph A., Seligson, David, Chakravari, Arnab, Lee, Francis Y., Weinmann, Roberto, Cloughesy, Timothy F., Nelson, Stanley F., Bergers, Gabriele, Graeber, Thomas, Furnari, Frank B., James, C. David, Cavenee, Webster K., Johns, Terrance G., Mischel, Paul S.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770839/
https://ncbi.nlm.nih.gov/pubmed/19690143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-0347
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