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Refining genome-wide associated loci for serum uric acid in individuals with African ancestry

OBJECTIVE: Serum uric acid is the end-product of purine metabolism and at high levels is a risk factor for several human diseases including gout and cardiovascular disease. Heritability estimates range from 0.32 to 0.63. Genome-wide association studies (GWAS) provide an unbiased approach to identify...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Chen, Guanjie, Shriner, Daniel, Doumatey, Ayo P, Zhou, Jie, Bentley, Amy R, Lei, Lin, Adeyemo, Adebowale, Rotimi, Charles N
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7015846/
https://ncbi.nlm.nih.gov/pubmed/31841133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz272
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