Phenotypic variance explained by local ancestry in admixed African Americans

We surveyed 26 quantitative traits and disease outcomes to understand the proportion of phenotypic variance explained by local ancestry in admixed African Americans. After inferring local ancestry as the number of African-ancestry chromosomes at hundreds of thousands of genotyped loci across all aut...

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Autori principali: Daniel eShriner, Amy R. Bentley, Ayo Priscille Doumatey, Guanjie eChen, Jie eZhou, Adebowale eAdeyemo, Charles N. Rotimi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2015-10-01
Serie:Frontiers in Genetics
Soggetti:
Health Disparities
complex traits
ancestry
random effects
phenotypic variance explained
Accesso online:http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00324/full
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