Mathematical deconvolution of CAR T-cell proliferation and exhaustion from real-time killing assay data

Chimeric antigen receptor (CAR) T-cell therapy has shown promise in the treatment of haematological cancers and is currently being investigated for solid tumours, including high-grade glioma brain tumours. There is a desperate need to quantitatively study the factors that contribute to the efficacy...

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Detalles Bibliográficos
Publicado en:J R Soc Interface
Autores principales: Sahoo, Prativa, Yang, Xin, Abler, Daniel, Maestrini, Davide, Adhikarla, Vikram, Frankhouser, David, Cho, Heyrim, Machuca, Vanessa, Wang, Dongrui, Barish, Michael, Gutova, Margarita, Branciamore, Sergio, Brown, Christine E., Rockne, Russell C.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Royal Society 2020
Materias:
Life Sciences–Mathematics interface
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7014796/
https://ncbi.nlm.nih.gov/pubmed/31937234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2019.0734
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