Nucleotide Sugar Pucker Preference Mitigates Excision by HIV-1 RT

A series of DNA primers containing nucleotides with various sugar pucker conformations at the 3′-terminus were chemically synthesized by solid-phase synthesis. The ability of wild-type (WT) HIV-1 reverse transcriptase (RT) and AZT-resistant (AZTr) RT to excise the 3′-terminal nucleotide was assessed...

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Publicat a:ACS Chem Biol
Autors principals: Yamada, Ken, Wahba, Alexander S., Bernatchez, Jean A., Ilina, Tatiana, Martínez-Montero, Saúl, Habibian, Maryam, Deleavey, Glen F., Götte, Matthias, Parniak, Michael A., Damha, Masad J.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012501/
https://ncbi.nlm.nih.gov/pubmed/26131619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00263
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