High activation of STAT5A drives peripheral T-cell lymphoma and leukemia

Recurrent gain-of-function mutations in the transcription factors STAT5A and much more in STAT5B were found in hematopoietic malignancies with the highest proportion in mature T- and natural killer-cell neoplasms (peripheral T-cell lymphoma, PTCL). No targeted therapy exists for these heterogeneous...

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Publicado no:Haematologica
Main Authors: Maurer, Barbara, Nivarthi, Harini, Wingelhofer, Bettina, Pham, Ha Thi Thanh, Schlederer, Michaela, Suske, Tobias, Grausenburger, Reinhard, Schiefer, Ana-Iris, Prchal-Murphy, Michaela, Chen, Doris, Winkler, Susanne, Merkel, Olaf, Kornauth, Christoph, Hofbauer, Maximilian, Hochgatterer, Birgit, Hoermann, Gregor, Hoelbl-Kovacic, Andrea, Prochazkova, Jana, Lobello, Cosimo, Cumaraswamy, Abbarna A., Latzka, Johanna, Kitzwögerer, Melitta, Chott, Andreas, Janikova, Andrea, Pospíšilova, Šárka, Loizou, Joanna I., Kubicek, Stefan, Valent, Peter, Kolbe, Thomas, Grebien, Florian, Kenner, Lukas, Gunning, Patrick T., Kralovics, Robert, Herling, Marco, Müller, Mathias, Rülicke, Thomas, Sexl, Veronika, Moriggl, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7012494/
https://ncbi.nlm.nih.gov/pubmed/31123029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.216986
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