STAT5B(N642H) is a driver mutation for T cell neoplasia

STAT5B is often mutated in hematopoietic malignancies. The most frequent STAT5B mutation, Asp642His (N642H), has been found in over 90 leukemia and lymphoma patients. Here, we used the Vav1 promoter to generate transgenic mouse models that expressed either human STAT5B or STAT5B(N642H) in the hemato...

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Publicat a:J Clin Invest
Autors principals: Pham, Ha Thi Thanh, Maurer, Barbara, Prchal-Murphy, Michaela, Grausenburger, Reinhard, Grundschober, Eva, Javaheri, Tahereh, Nivarthi, Harini, Boersma, Auke, Kolbe, Thomas, Elabd, Mohamed, Halbritter, Florian, Pencik, Jan, Kazemi, Zahra, Grebien, Florian, Hengstschläger, Markus, Kenner, Lukas, Kubicek, Stefan, Farlik, Matthias, Bock, Christoph, Valent, Peter, Müller, Mathias, Rülicke, Thomas, Sexl, Veronika, Moriggl, Richard
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5749501/
https://ncbi.nlm.nih.gov/pubmed/29200404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94509
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