Structural and functional consequences of the STAT5B(N642H) driver mutation

Hyper-activated STAT5B variants are high value oncology targets for pharmacologic intervention. STAT5B(N642H), a frequently-occurring oncogenic driver mutation, promotes aggressive T-cell leukemia/lymphoma in patient carriers, although the molecular origins remain unclear. Herein, we emphasize the a...

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Publicado no:Nat Commun
Main Authors: de Araujo, Elvin D., Erdogan, Fettah, Neubauer, Heidi A., Meneksedag-Erol, Deniz, Manaswiyoungkul, Pimyupa, Eram, Mohammad S., Seo, Hyuk-Soo, Qadree, Abdul K., Israelian, Johan, Orlova, Anna, Suske, Tobias, Pham, Ha T. T., Boersma, Auke, Tangermann, Simone, Kenner, Lukas, Rülicke, Thomas, Dong, Aiping, Ravichandran, Manimekalai, Brown, Peter J., Audette, Gerald F., Rauscher, Sarah, Dhe-Paganon, Sirano, Moriggl, Richard, Gunning, Patrick T.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555848/
https://ncbi.nlm.nih.gov/pubmed/31175292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10422-7
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