Structural and functional consequences of the STAT5B(N642H) driver mutation

Hyper-activated STAT5B variants are high value oncology targets for pharmacologic intervention. STAT5B(N642H), a frequently-occurring oncogenic driver mutation, promotes aggressive T-cell leukemia/lymphoma in patient carriers, although the molecular origins remain unclear. Herein, we emphasize the a...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: de Araujo, Elvin D., Erdogan, Fettah, Neubauer, Heidi A., Meneksedag-Erol, Deniz, Manaswiyoungkul, Pimyupa, Eram, Mohammad S., Seo, Hyuk-Soo, Qadree, Abdul K., Israelian, Johan, Orlova, Anna, Suske, Tobias, Pham, Ha T. T., Boersma, Auke, Tangermann, Simone, Kenner, Lukas, Rülicke, Thomas, Dong, Aiping, Ravichandran, Manimekalai, Brown, Peter J., Audette, Gerald F., Rauscher, Sarah, Dhe-Paganon, Sirano, Moriggl, Richard, Gunning, Patrick T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555848/
https://ncbi.nlm.nih.gov/pubmed/31175292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10422-7
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky