Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2,4,6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor

Pyridinium containing sulfonamides have been largely investigated as carbonic anhydrase inhibitors (CAIs), showing interesting selectivity features. Nevertheless, only few structural studies are so far available on adducts that these compounds form with diverse CA isoforms. In this paper, we report...

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Bibliographische Detailangaben
Veröffentlicht in:J Enzyme Inhib Med Chem
Hauptverfasser: Alterio, Vincenzo, Esposito, Davide, Monti, Simona Maria, Supuran, Claudiu T., De Simone, Giuseppina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
Schlagworte:
Short Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011996/
https://ncbi.nlm.nih.gov/pubmed/29199489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1405263
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