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Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2,4,6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor

Pyridinium containing sulfonamides have been largely investigated as carbonic anhydrase inhibitors (CAIs), showing interesting selectivity features. Nevertheless, only few structural studies are so far available on adducts that these compounds form with diverse CA isoforms. In this paper, we report...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Alterio, Vincenzo, Esposito, Davide, Monti, Simona Maria, Supuran, Claudiu T., De Simone, Giuseppina
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011996/
https://ncbi.nlm.nih.gov/pubmed/29199489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1405263
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