Crystal structure of the human carbonic anhydrase II adduct with 1-(4-sulfamoylphenyl-ethyl)-2,4,6-triphenylpyridinium perchlorate, a membrane-impermeant, isoform selective inhibitor

Pyridinium containing sulfonamides have been largely investigated as carbonic anhydrase inhibitors (CAIs), showing interesting selectivity features. Nevertheless, only few structural studies are so far available on adducts that these compounds form with diverse CA isoforms. In this paper, we report...

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Détails bibliographiques
Publié dans:J Enzyme Inhib Med Chem
Auteurs principaux: Alterio, Vincenzo, Esposito, Davide, Monti, Simona Maria, Supuran, Claudiu T., De Simone, Giuseppina
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2017
Sujets:
Short Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011996/
https://ncbi.nlm.nih.gov/pubmed/29199489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1405263
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