A Class of 4-Sulfamoylphenyl-ω-aminoalkyl Ethers with Effective Carbonic Anhydrase Inhibitory Action and Antiglaucoma Effects

[Image: see text] We report a series of 4-sulfamoylphenyl-ω-aminoalkyl ethers as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. The structure–activity relationship was drawn for the inhibition of four physiologically relevant isoforms: hCA I, II, IX, and XII. Many of these compounds were highly eff...

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Detaylı Bibliyografya
Yayımlandı:J Med Chem
Asıl Yazarlar: Bozdag, Murat, Pinard, Melissa, Carta, Fabrizio, Masini, Emanuela, Scozzafava, Andrea, McKenna, Robert, Supuran, Claudiu T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2014
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255726/
https://ncbi.nlm.nih.gov/pubmed/25358036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501497m
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