Structural basis of Dot1L stimulation by histone H2B lysine 120 ubiquitination

The essential histone H3 lysine 79 methyltransferase Dot1L regulates transcription and genomic stability and is deregulated in leukemia. The activity of Dot1L is stimulated by mono-ubiquitination of histone H2B on lysine 120 (H2BK120Ub); however, the detailed mechanism is not understood. We report c...

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Detaylı Bibliyografya
Yayımlandı:Mol Cell
Asıl Yazarlar: Valencia-Sánchez, Marco Igor, De Ioannes, Pablo, Wang, Miao, Vasilyev, Nikita, Chen, Ruoyu, Nudler, Evgeny, Armache, Jean-Paul, Armache, Karim-Jean
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7009778/
https://ncbi.nlm.nih.gov/pubmed/30981630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.03.029
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