Structural basis of Dot1L stimulation by histone H2B lysine 120 ubiquitination

The essential histone H3 lysine 79 methyltransferase Dot1L regulates transcription and genomic stability and is deregulated in leukemia. The activity of Dot1L is stimulated by mono-ubiquitination of histone H2B on lysine 120 (H2BK120Ub); however, the detailed mechanism is not understood. We report c...

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Udgivet i:Mol Cell
Main Authors: Valencia-Sánchez, Marco Igor, De Ioannes, Pablo, Wang, Miao, Vasilyev, Nikita, Chen, Ruoyu, Nudler, Evgeny, Armache, Jean-Paul, Armache, Karim-Jean
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7009778/
https://ncbi.nlm.nih.gov/pubmed/30981630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.03.029
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