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Structural basis of Dot1L stimulation by histone H2B lysine 120 ubiquitination
The essential histone H3 lysine 79 methyltransferase Dot1L regulates transcription and genomic stability and is deregulated in leukemia. The activity of Dot1L is stimulated by mono-ubiquitination of histone H2B on lysine 120 (H2BK120Ub); however, the detailed mechanism is not understood. We report c...
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| Pubblicato in: | Mol Cell |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7009778/ https://ncbi.nlm.nih.gov/pubmed/30981630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.03.029 |
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