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γ-Secretase and its modulators: Twenty years and beyond
Twenty years ago, Wolfe, Xia, and Selkoe identified two aspartate residues in Alzheimer’s presenilin protein that constitute the active site of the γ-secretase complex. Mutations in the genes encoding amyloid precursor protein (APP) or presenilin (PS) cause early onset familial Alzheimer’s disease (...
Gorde:
| Argitaratua izan da: | Neurosci Lett |
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| Egile nagusia: | |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2019
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7008970/ https://ncbi.nlm.nih.gov/pubmed/30763650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2019.02.011 |
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