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Cryo-EM structure of the human FLCN-FNIP2-Rag-Ragulator complex
mTORC1 controls anabolic and catabolic processes in response to nutrients through the Rag GTPase heterodimer, which is regulated by multiple upstream protein complexes. One such regulator, FLCN-FNIP2, is a GTPase activating protein (GAP) for RagC/D, but despite its important role, how it activates t...
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| Pubblicato in: | Cell |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7008705/ https://ncbi.nlm.nih.gov/pubmed/31704029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.10.036 |
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