Caricamento...
Cl(−) and H(+) coupling properties and subcellular localizations of wildtype and disease-associated variants of the voltage-gated Cl(−)/H(+) exchanger ClC-5
Dent disease 1 (DD1) is caused by mutations in the CLCN5 gene encoding a voltage-gated electrogenic nCl(−)/H(+) exchanger ClC-5. Using ion-selective microelectrodes and Xenopus oocytes, here we studied Cl(−)/H(+) coupling properties of WT ClC-5 and four DD1-associated variants (S244L, R345W, Q629*,...
Salvato in:
| Pubblicato in: | J Biol Chem |
|---|---|
| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2020
|
| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7008381/ https://ncbi.nlm.nih.gov/pubmed/31852738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011366 |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !
|