Cl(−) and H(+) coupling properties and subcellular localizations of wildtype and disease-associated variants of the voltage-gated Cl(−)/H(+) exchanger ClC-5

Dent disease 1 (DD1) is caused by mutations in the CLCN5 gene encoding a voltage-gated electrogenic nCl(−)/H(+) exchanger ClC-5. Using ion-selective microelectrodes and Xenopus oocytes, here we studied Cl(−)/H(+) coupling properties of WT ClC-5 and four DD1-associated variants (S244L, R345W, Q629*,...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Chang, Min-Hwang, Brown, Matthew R., Liu, Yiran, Gainullin, Vladimir G., Harris, Peter C., Romero, Michael F., Lieske, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7008381/
https://ncbi.nlm.nih.gov/pubmed/31852738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011366
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