Chronic Dicer1 deficiency promotes atrophic and neovascular outer retinal pathologies in mice

Degeneration of the retinal pigmented epithelium (RPE) and aberrant blood vessel growth in the eye are advanced-stage processes in blinding diseases such as age-related macular degeneration (AMD), which affect hundreds of millions of people worldwide. Loss of the RNase DICER1, an essential factor in...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Wright, Charles B., Uehara, Hironori, Kim, Younghee, Yasuma, Tetsuhiro, Yasuma, Reo, Hirahara, Shuichiro, Makin, Ryan D., Apicella, Ivana, Pereira, Felipe, Nagasaka, Yosuke, Narendran, Siddharth, Fukuda, Shinichi, Albuquerque, Romulo, Fowler, Benjamin J., Bastos-Carvalho, Ana, Georgel, Philippe, Hatada, Izuho, Chang, Bo, Kerur, Nagaraj, Ambati, Balamurali K., Ambati, Jayakrishna, Gelfand, Bradley D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007521/
https://ncbi.nlm.nih.gov/pubmed/31964819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909761117
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