TLR-Independent and P2X7-Dependent Signaling Mediate Alu RNA-Induced NLRP3 Inflammasome Activation in Geographic Atrophy

PURPOSE. Accumulation of Alu RNA transcripts due to DICER1 deficiency in the retinal pigmented epithelium (RPE) promotes geographic atrophy. Recently we showed that Alu RNA activated the NLRP3 inflammasome, leading to RPE cell death via interleukin-18 (IL-18)-mediated MyD88 signaling. However, the m...

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Auteurs principaux: Kerur, Nagaraj, Hirano, Yoshio, Tarallo, Valeria, Fowler, Benjamin J., Bastos-Carvalho, Ana, Yasuma, Tetsuhiro, Yasuma, Reo, Kim, Younghee, Hinton, David R., Kirschning, Carsten J., Gelfand, Bradley D., Ambati, Jayakrishna
Format: Artigo
Langue:Inglês
Publié: The Association for Research in Vision and Ophthalmology 2013
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3825570/
https://ncbi.nlm.nih.gov/pubmed/24114535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-12500
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