DICER1/Alu RNA dysmetabolism induces Caspase-8–mediated cell death in age-related macular degeneration

Geographic atrophy, an advanced form of age-related macular degeneration (AMD) characterized by death of the retinal pigmented epithelium (RPE), causes untreatable blindness in millions worldwide. The RPE of human eyes with geographic atrophy accumulates toxic Alu RNA in response to a deficit in the...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kim, Younghee, Tarallo, Valeria, Kerur, Nagaraj, Yasuma, Tetsuhiro, Gelfand, Bradley D., Bastos-Carvalho, Ana, Hirano, Yoshio, Yasuma, Reo, Mizutani, Takeshi, Fowler, Benjamin J., Li, Shengjian, Kaneko, Hiroki, Bogdanovich, Sasha, Ambati, Balamurali K., Hinton, David R., Hauswirth, William W., Hakem, Razqallah, Wright, Charles, Ambati, Jayakrishna
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234570/
https://ncbi.nlm.nih.gov/pubmed/25349431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403814111
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