TLR-Independent and P2X7-Dependent Signaling Mediate Alu RNA-Induced NLRP3 Inflammasome Activation in Geographic Atrophy

PURPOSE. Accumulation of Alu RNA transcripts due to DICER1 deficiency in the retinal pigmented epithelium (RPE) promotes geographic atrophy. Recently we showed that Alu RNA activated the NLRP3 inflammasome, leading to RPE cell death via interleukin-18 (IL-18)-mediated MyD88 signaling. However, the m...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Kerur, Nagaraj, Hirano, Yoshio, Tarallo, Valeria, Fowler, Benjamin J., Bastos-Carvalho, Ana, Yasuma, Tetsuhiro, Yasuma, Reo, Kim, Younghee, Hinton, David R., Kirschning, Carsten J., Gelfand, Bradley D., Ambati, Jayakrishna
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Association for Research in Vision and Ophthalmology 2013
Onderwerpen:
Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3825570/
https://ncbi.nlm.nih.gov/pubmed/24114535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.13-12500
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items