GeneORator: An Effective Strategy for Navigating Protein Sequence Space More Efficiently through Boolean OR-Type DNA Libraries

[Image: see text] Directed evolution requires the creation of genetic diversity and subsequent screening or selection for improved variants. For DNA mutagenesis, conventional site-directed methods implicitly utilize the Boolean AND operator (creating all mutations simultaneously), producing a combin...

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Détails bibliographiques
Publié dans:ACS Synth Biol
Auteurs principaux: Currin, Andrew, Kwok, Jane, Sadler, Joanna C., Bell, Elizabeth L., Swainston, Neil, Ababi, Maria, Day, Philip, Turner, Nicholas J., Kell, Douglas B.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2019
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007284/
https://ncbi.nlm.nih.gov/pubmed/31132850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssynbio.9b00063
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