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Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently

The amino acid sequence of a protein affects both its structure and its function. Thus, the ability to modify the sequence, and hence the structure and activity, of individual proteins in a systematic way, opens up many opportunities, both scientifically and (as we focus on here) for exploitation in...

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Detalhes bibliográficos
Publicado no:Chem Soc Rev
Main Authors: Currin, Andrew, Swainston, Neil, Day, Philip J., Kell, Douglas B.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349129/
https://ncbi.nlm.nih.gov/pubmed/25503938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cs00351a
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