Amino acid residues involved in the heparin-binding activity of murine IL-12 in the context of an antibody-cytokine fusion protein

An antibody-cytokine fusion protein, composed of the murine single-chain cytokine interleukin-12 (IL-12) genetically fused to a human IgG3 specific for the human tumor-associated antigen HER2/neu maintains antigen binding, cytokine, bioactivity, and IL-12 heparin-binding activity. This latter proper...

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Detalhes bibliográficos
Publicado no:Cytokine
Main Authors: Luria-Pérez, Rosendo, Candelaria, Pierre V., Daniels-Wells, Tracy R., Rodríguez, José A., Helguera, Gustavo, Penichet, Manuel L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007190/
https://ncbi.nlm.nih.gov/pubmed/31121497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cyto.2019.04.004
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