Insights into the mechanism of cell death induced by saporin delivered into cancer cells by an antibody fusion protein targeting the transferrin receptor 1

We previously developed an antibody-avidin fusion protein (ch128.1Av) that targets the human transferrin receptor 1 (TfR1) and exhibits direct cytotoxicity against malignant B cells in an iron-dependent manner. ch128.1Av is also a delivery system and its conjugation with biotinylated saporin (b-SO6)...

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Detalhes bibliográficos
Main Authors: Daniels-Wells, Tracy R., Helguera, Gustavo, Rodríguez, José A., Leoh, Lai Sum, Erb, Michael A., Diamante, Graciel, Casero, David, Pellegrini, Matteo, Martínez-Maza, Otoniel, Penichet, Manuel L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3513587/
https://ncbi.nlm.nih.gov/pubmed/23085102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tiv.2012.10.006
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